What is Retatrutide?
Retatrutide is a next-generation peptide currently under clinical investigation for its potent effects on weight loss, blood sugar regulation, and metabolic optimization. It functions as a triple receptor agonist, activating GLP-1, GIP, and glucagon receptors, which work together to regulate appetite, energy expenditure, and insulin sensitivity.
Originally developed for type 2 diabetes and obesity, Retatrutide has shown unprecedented results in early clinical trials, with participants achieving substantial reductions in body weight, improved insulin resistance, and better glycemic control.
How Retatrutide Works
Retatrutide mimics three key metabolic hormones to:
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Suppress appetite and reduce cravings
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Enhance insulin sensitivity and lower blood glucose levels
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Increase resting energy expenditure and promote fat oxidation
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Slow gastric emptying, which leads to earlier satiety and smaller food intake
 
This triple-action mechanism places Retatrutide at the forefront of obesity and metabolic disease research.
Administration and Dosage Guidelines
Retatrutide is administered via subcutaneous injection once per week. It must be reconstituted with sterile water for injection and dosed according to established titration protocols from current clinical studies.
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Start low and titrate gradually to minimize side effects.
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Typical starting dose: 1.5–2.5 mg per week, with gradual increases every 4 weeks depending on individual tolerance and goals.
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In research settings, final maintenance doses typically range from 6–12 mg/week.
 
Potential Side Effects (Mild and Manageable)
Common, usually temporary effects may include: Nausea, Diarrhea or loose stools, Fatigue, Mild headache, Decreased appetite, Feeling cold.
These are typically dose-dependent and resolve as your body adjusts. Hydration, small meals, and electrolyte support can help during the first few weeks of titration.
Safety Considerations
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Not recommended during pregnancy or breastfeeding
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Consult your healthcare provider if you have a history of thyroid tumors, pancreatitis, or severe gastrointestinal disease
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Retatrutide may interact with other medications, especially those for diabetes or blood pressure—please disclose all medications prior to use.
 
Storage & Handling
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Store reconstituted vials in the refrigerator (2°C–8°C)
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Do not freeze
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Protect from direct light
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Allow to reach room temperature before administering
 
Missed a Dose?
If a dose is missed, administer it as soon as possible unless it’s close to the next scheduled dose. Do not double up to compensate.
A Note on Availability
While Retatrutide is currently in clinical trials, it is available for research and off-label use through licensed compounding partners. All vials are manufactured in a licensed South African compounding pharmacy, tested for purity, sterility, and accuracy.
Please note: This product is provided strictly for research and educational purposes and is not approved for treatment of any medical condition without the oversight of a licensed healthcare provider.
USE OF RETATRUTIDE FOR BLOOD SUGAR CONTROL IN DIABETICS MUST BE PRESCRIBED AND MANAGED BY A QUALIFIED MEDICAL PROFESSIONAL. SHIFA CANNOT SUPPLY THIS PRODUCT FOR SUCH USE WITHOUT A VALID PRESCRIPTION AND AUTHORIZATION.





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